How does Sermorelin compare to Tesamorelin regarding possible properties, such as fatty tissue reduction and muscle cell development? This in-depth analysis will compare and contrast these two potent research peptides, highlighting their distinctions and discussing their theorized actions. Ultimately, our go-to source for research-grade peptides like Sermorelin and Tesamorelin will also be recommended.
Sermorelin Peptide: What is it?
Synthetic growth hormone-releasing hormone (GHRH) peptide Sermorelin, sometimes called growth hormone-releasing factor 1-29 (GRF1-29), contains the first 29 amino acids of the naturally occurring hormone. The main regulator of growth hormone (GH) production is physiological GHRH secretion.
As the smallest functional portion of GHRH's 44 amino acid sequence, Sermorelin is hypothesized to increase GH release and was first produced by pharmaceutical firm EMD Serono. Aside from its shorter structure, Sermorelin has a half-life with GHRH, as suggested by research.
Tesamorelin Peptide: What is it?
With the same 44 amino acid makeup as GHRH, Tesamorelin (TH9507) is an improved synthetic form of the hormone with a trans-3-hexenoic acid connection to its N-terminus. Studies have shown that this change makes Tesamorelin more resistant to degradation and increases its affinity for its target receptors.
Investigations purport that Tesamorelin may stimulate somatotroph cells to secrete more growth hormone by interacting with GHRH receptors in the pituitary gland; this effect is believed to last 30 to 40 minutes. GH secretion is hypothesized to peak about half an hour to an hour after presentation. The Canadian company Theratechnologies created Tesamorelin for study in the context of lipodystrophy linked to HIV/AIDS in preclinical animal research.
One symptom of lipodystrophy is an uneven distribution of fat. Fat deposits around internal organs and a marked reduction in fat in other places are the telltale signs of this condition.
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Some antiretroviral compounds are thought to induce lipodystrophy in HIV/AIDS research models. The most problematic part of this disorder is visceral obesity, which is defined as an excess of fat around and inside the internal organs. Metabolic problems, including insulin resistance and type 2 diabetes, might develop as a result of this.
A Comprehensive Comparison of Sermorelin and Tesamorelin
Findings imply that two agonists at the GHRH receptor may promote the organism's natural synthesis of growth hormone: Sermorelin and Tesamorelin. GH may be undetected between pulses. Therefore, it is impossible to determine the entire GH levels of test subjects from only one GH measurement.
To determine the potential impact of peptides like Sermorelin or Tesamorelin on the production of GH, researchers must instead conduct a battery of studies over an extended period. Afterward, the data may be shown on a graph to illustrate the change in GH levels over time. A comprehensive view of the total GH release over time may be obtained by calculating the area under this graphed line, also called the "area under the curve" (AUC).
Clinical studies indicate that Sermorelin and Tesamorelin may affect total pulse area and AUC. However, they do not seem to raise heart rate or induce GH levels over normal. Furthermore, insulin-like growth factor-1 (IGF-1) is an anabolic hormone that GH has been theorized to promote the synthesis of. However, scientists speculate the levels of IGF-1 may be dependent on average GH levels and do not follow the same pulsatile pattern. For this reason, they hypothesize that increasing growth hormone synthesis is another possible application of IGF-1.
It is also believed that IGF-1 might mediate most of the anabolic effects of GH, including the possibility of gaining lean body mass. To keep up with the most recent findings, below is how Sermorelin and Tesamorelin have been hypothesized to affect GH and IGF-1 levels:
- Sermorelin appeared to have increased total GH levels (as assessed by AUC) by 82% after 6 weeks of daily presentations. Findings implied that the increase in GH levels appeared to have lasted for around two hours after the presentation.
- A substantial rise in GH and IGF-1 was observed when given Sermorelin. Researchers speculated that the highest concentration seemed to have resulted in a 25% rise in IGF-1.
- Another study's findings implied that a 69% increase in total GH (AUC) after two weeks of presentation of Tesamorelin. It was speculated that IGF-1 levels also appeared to rise a whopping 122%.
- Animal research models of type 2 diabetes were also given Tesamorelin. The results of this study purported that twelve weeks of presentation appeared to result in a 60% rise in IGF-1.
Research suggests that Tesamorelin and Sermorelin may boost GH and IGF-1 at different rates. Visit www.corepeptides.com for more educational articles and high-quality research compounds.
